The Orbs of Destruction are orbs with amazing power and were created when the 10 original Kais created the universe. Anyone who can combine all the orbs will have almost unlimited power, such as immortality and reality alteration.
The original 10 Kais turned into orbs so that they wouldn't abuse their great power. They banned all Kais from using them, but they couldn't do so for the other gods. The other gods combined their powers to create a monster called Xeon, who broke the seal.